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Chondroitin Sulfate exists naturally in your cartilage. It’s thought to draw fluid into the tissue to give our cartilage more elasticity and to slow cartilage breakdown by protecting it from destructive enzymes. As a supplement, it is exclusively derived from cattle sources and is often taken along with Glucosamine to assist with maintaining joint health. The combined use is known to produce a "synergistic" effect. It’s been prescribed for pain relief in osteoarthritis in some parts of Europe where it is a prescription drug for decades. If glucosamine is your #1 joint friend, chondroitin is #2.

Although Chondroitin alone hasn't been proven to help with or reverse cartilage loss, in some studies it appeared to help improve function and ease pain. In one placebo-controlled study, joint narrowing in the knee became stabilized in patients who were put on Chondroitin (Uebelhart) supplement. Another controlled study looked at osteoarthritis of the finger joints for a period of three years. Among the group that took chondroitin, there was a significant decrease in the number of patients with new erosions in their finger joints (Verbruggen).

Chondroitin in fact is a glycosaminoglycan (think long chains of glucosamine) that is concentrated in joint cartilage. Like glucosamine, chondroitin helps produce substances needed for the formation of connective tissue. In addition chondroitin (unlike glucosamine) may also have the ability to protect existing cartilage from prematurely breaking down by inhibiting cartilage-destroying enzymes.

How Does Chondroitin Work?

Chondroitin sulfates provide the structural components of joint cartilage, inhibit some free radical enzymes that degrade joint cartilage and collagen, and facilitate the entry of glucosamine into the joints. Like glucosamine, chondroitin sulfate attracts water into the cartilage matrix and stimulates the production of cartilage. It also appears to have the ability to prevent enzymes from dissolving cartilage. Recent studies have shown extremely good results from long-term use of chondroitin sulfate (alone and in combination with glucosamine) in increasing range of motion and overall joint health. Both glucosamine and chondroitin should be used together, however, to produce the best results.

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